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Moumoujus

6-AMINO-M-CRESOL.

Avoid CAS 2835-98-5 / HAIR DYEING

A synthetic aminophenol compound primarily developed as an oxidative hair dye precursor that forms colored pigment molecules when activated by peroxide. This ingredient has significant safety concerns for topical use, including strong sensitization potential and genotoxic risk through its metabolites.

Summary

hair colouring

Science

Mechanism of Action

Functions as a dye intermediate that penetrates hair shafts and undergoes oxidative coupling to create permanent color molecules. On skin, it acts as a potent contact allergen and generates potentially harmful metabolites including N-acetyl-2-amino-5-methylphenol.

Research

Clinical Evidence

High confidence
Effective range 0.75–1.5%
Optimal

N/A

Key findings

  1. 01 LLNA sensitization testing showed EC3 values of 1.55-3.44%, confirming strong allergenic potential
  2. 02 Dermal penetration studies at 0.75% demonstrated 0.34% absorption (2.77 µg/cm²) in hair dye formulations
  3. 03 SCCS evaluation at 1.5% maximum concentration deemed unsafe for cosmetic use due to genotoxic concerns

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.1%

This ingredient should trigger immediate concern at any concentration in skincare due to prohibited status in EU and significant safety risks

The Formula

Formulation

Solubility
Both
Optimal pH 7 – 9.5
0 7 14

Stability

Extremely unstable in aqueous solutions with 30% degradation within 48 hours at room temperature. Requires dry storage with light protection for long-term stability.

Conflicts

  • Strong oxidizing agents
  • Acidic pH environments
  • Light exposure

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1.3%
Pregnancy
Caution
Sensitization risk High

Prohibited in EU cosmetics (Annex II) due to genotoxicity and sensitization. CIR allows up to 1.3% in hair dyes only, not skincare products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Inappropriate for precision skincare due to strong sensitization potential, genotoxic concerns, and regulatory restrictions in cosmetic applications.

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