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5-PHENYLHEX-4-EN-2-ONE.

Optional CAS 35151-11-2 / PERFUMING

An unsaturated ketone compound primarily utilized as a fragrance ingredient in cosmetic formulations. This aromatic molecule serves as both a scenting agent and masking component, helping to neutralize undesirable odors from other ingredients while contributing its own characteristic fragrance profile.

Perfuming Masking

Science

Functions primarily through olfactory interaction, providing fragrance masking properties in formulations. As an unsaturated ketone with Michael acceptor potential, it may form minor interactions with skin proteins, though at typical cosmetic concentrations this activity is minimal and the primary function remains aromatic.


Research

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 RIFM safety assessment (2020) demonstrating no sensitization concerns at declared use levels up to 1.0%

Transparency

Not commonly dusted

As a fragrance component rather than active ingredient, dusting concerns are minimal since efficacy claims are not typically made for this ingredient


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Susceptible to oxidative degradation due to unsaturated ketone structure. Performs optimally in oil-based systems or well-stabilized emulsions. Avoid exposure to intense UV light and highly alkaline conditions to prevent color changes.

Synergies

  • Other fragrance components
  • Oil-based carriers
  • Antioxidants for stability enhancement

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Cysteamine and nucleophilic compounds

Safety

CIR Status
Not reviewed
Max tested
0.5%
Pregnancy
Safe
Sensitization risk Low

RIFM assessment confirms safety at current use levels. Subject to IFRA fragrance ingredient standards. Higher concentrations above 350 mg/kg systemically may cause dermal irritation.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient suitable for most skin types when used within established concentration limits.


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References