Science
Mechanism of Action
Disrupts microbial cell membranes through plasmolysis while simultaneously modulating inflammatory pathways by inhibiting key cytokines (IL-1β, IL-6, IL-8, TNF-α) and suppressing monocyte superoxide production. May enhance dermal matrix integrity by stimulating procollagen synthesis and reducing MMP-1 expression.
Research
Clinical Evidence
High confidence1.5%
Key findings
- 01 99% microbial load reduction at 2% concentration with zero irritation score (RIPT 0.0)
- 02 Superior Demodex mite elimination at 1% versus equivalent tea tree oil concentrations
- 03 Complete absence of erythema and edema at 1.5% after 48-hour patch testing
Transparency
Dusting Analysis
Well-established ingredient with clear concentration guidelines and clinical validation
The Formula
Formulation
Stability
Superior stability compared to crude tea tree oil; requires protection from light and oxygen to prevent p-cymene conversion; gel and aqueous formulations show better stability than cream bases
Conflicts
- alpha-terpineol (antagonistic antimicrobial effects)
- high-fat cream bases (accelerated degradation)
Safety
Safety Profile
Significantly less sensitizing than whole tea tree oil; SCCS recommends 2.0% maximum for rinse-off applications with lower limits for leave-on products
Your Skin
Skin Compatibility
Our Assessment
Verdict
A clinically-validated, well-tolerated antimicrobial that offers the benefits of tea tree oil without the associated irritation risks.
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References
Sources