New 50 ml glass bottles30-day money-back guarantee
Menu
Moumoujus

Ingredient directory

4-t-butylcyclohexanol

A specialized neuro-cosmetic ingredient that functions as a selective TRPV1 receptor antagonist, effectively interrupting pain and irritation signals at the neurological level. This crystalline alcohol demonstrates remarkable efficacy in reducing skin hypersensitivity and stinging sensations within minutes of application. Its targeted mechanism makes it particularly valuable for sensitive skin formulations and post-procedure recovery products.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

soothing emollient neuro-cosmetic

Science

Mechanism of Action

Selectively binds to and blocks Transient Receptor Potential Vanilloid 1 (TRPV1) channels in cutaneous nerve endings, raising the skin's sensitivity threshold and preventing the transmission of stinging, burning, and pain signals triggered by environmental irritants or thermal stimuli.

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

0.4%

Key findings

  1. 01 Randomized controlled trial (n=30) demonstrated significant reduction in capsaicin-induced irritation within 3 minutes at 0.4% concentration
  2. 02 Multi-subject study (n=66) showed 65% reduction in stinging scores and >90% improvement in hypersensitivity over 21 days
  3. 03 20-week clinical trial in seborrheic dermatitis patients showed enhanced hydration and reduced TEWL at 1.0% concentration

Transparency

Dusting Analysis

Not commonly dusted

Limited commercial availability and specialized application make dusting unlikely; requires proper solubilization techniques that discourage superficial inclusion.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Solid crystalline structure at ambient temperature requires pre-dissolution in lipophilic solvents, glycols, or ethanol before oil phase incorporation.

Synergies

  • licochalcone A

Conflicts

  • highly polar aqueous systems
  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

RIFM safety assessments confirm topical safety up to 1% concentration. Demonstrates non-genotoxic and non-phototoxic properties in standard testing protocols.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A scientifically sophisticated soothing agent with proven neurological mechanism and rapid-onset efficacy, particularly valuable for sensitive skin applications despite formulation complexity.

Related

Similar Ingredients

Finding similar ingredients…

References

Sources

Keep exploring

From ingredients to everyday care.

Sensitive skin ↗

Start with comfort, product choices and the questions to ask.

Barrier support ↗

Understand moisture, lipids and the limits of ingredient claims.

Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.