Science
Mechanism of Action
Absorbs UVB radiation between 290-320 nm with peak effectiveness at 301 nm, converting harmful UV energy into harmless heat while also stabilizing photosensitive ingredients like avobenzone in sunscreen formulations.
Research
Clinical Evidence
Medium confidence4%
Key findings
- 01 SCCS 2022 re-evaluation found higher systemic exposure than previously estimated at 4% concentration
- 02 Human pharmacokinetics study (Janjua 2008) demonstrated peak plasma levels within 6 hours of application
- 03 Animal studies showed endocrine disruption at 33 mg/kg oral dose with thyroid hormone interference
Transparency
Dusting Analysis
Not applicable for UV filters as they require specific concentrations for efficacy
The Formula
Formulation
Stability
Crystalline solid at room temperature with moderate photostability (10% degradation in 65 minutes). Maintains stability for 4+ years in original form.
Synergies
- Avobenzone (photostabilization)
Conflicts
- Highly aqueous systems without solubilizing agents
- Ethanol or glycol pre-dissolution required for water-based formulations
Safety
Safety Profile
Banned in EU (May 2025 for new products, May 2026 complete ban) due to endocrine disruption and genotoxicity concerns. Not FDA-approved in US. Approved in Australia and Canada up to 4%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite effective UVB protection, systemic absorption and endocrine disruption risks make this ingredient unsuitable for precision skincare formulations.
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