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4-FURANYLETHYL RESORCINOL.

Valuable CAS 1206193-05-6 / ANTIOXIDANT, SKIN CONDITIONING

A synthetic resorcinol derivative engineered to target hyperpigmentation through precise tyrosinase inhibition. This advanced brightening agent demonstrates superior melanin-blocking activity compared to traditional ingredients like kojic acid, while providing additional antioxidant protection against UV-induced pigmentation triggers.

skin brightening antioxidant tyrosinase inhibitor

Science

Functions as a competitive inhibitor of tyrosinase, the key enzyme controlling melanin production, specifically blocking the conversion of L-DOPA to melanin. Simultaneously provides antioxidant activity that neutralizes free radicals from UV exposure, addressing both primary and secondary pathways of pigmentation formation.


Research

Medium confidence
Effective range 0.1–0.5%
Optimal

0.5%

Key findings

  1. 01 At 0.5% concentration, in-vivo testing showed significant hyperpigmentation reduction and enhanced skin radiance, outperforming 1% kojic acid
  2. 02 Demonstrated superior tyrosinase inhibition in human melanocyte cultures compared to arbutin across 0.1-0.5% range

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Effective concentrations start at 0.1% with optimal results at 0.5%, making dusting unlikely to provide meaningful brightening benefits


The Formula

Solubility
Oil
Optimal pH 4 – 6
0 7 14

Stability

Extremely light and oxidation sensitive, prone to yellow/brown discoloration when exposed to air. Requires opaque, airless packaging and stabilization with chelating agents or antioxidants.

Synergies

  • EDTA (chelating)
  • Vitamin E (antioxidant stabilization)

Conflicts

  • Strong oxidizing agents
  • Alkaline pH environments above 7.0
  • Iron-containing ingredients

Safety

CIR Status
Not reviewed - belongs to resorcinol derivative family
Max tested
0.5%
Sensitization risk Low

Approved in China and EU markets with 0.5% concentration limits for leave-on products due to potential sensitization at higher levels


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

A potent, clinically-backed brightening agent that outperforms traditional alternatives, though formulation complexity and sensitivity concerns limit broader accessibility.


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References