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Moumoujus

Ingredient directory

4-ethylphenol

A phenolic compound primarily used as a fragrance component and antimicrobial agent in cosmetic formulations. Research suggests potential depigmenting properties through tyrosinase inhibition and cAMP pathway modulation, though this remains largely experimental.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

perfuming antimicrobial

Science

Functions as an antimicrobial by increasing microbial cell membrane permeability while providing fragrance benefits. Preliminary research indicates it may inhibit tyrosinase enzyme activity and reduce cAMP levels by approximately 20%, potentially affecting melanin production through PKA pathway attenuation.


Research

Low confidence
Effective range 0.05–1%
Optimal

0.05%

Key findings

  1. 01 Demonstrated 20% reduction in cAMP levels in vitro, suggesting anti-hyperpigmentary potential

Transparency

Not commonly dusted

Primarily used in fragrance applications rather than active skincare formulations


The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Demonstrates excellent stability under standard conditions but exhibits photosensitivity leading to yellowing. Most effective in non-ionized form given pKa of approximately 10.0.

Conflicts

  • strong oxidizing agents
  • acid chlorides
  • acid anhydrides
  • bases

Safety

CIR Status
Not reviewed
Max tested
0.05%
Sensitization risk Moderate

RIFM considers safe at fragrance concentrations up to 0.05%. Higher concentrations pose risk of chemical vitiligo through T-cell mediated melanocyte damage.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Limited to fragrance applications due to moderate irritancy and potential for chemical vitiligo at effective concentrations.


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