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Moumoujus

4-ETHYLGUAIACOL.

Optional CAS 2785-89-9 / PERFUMING

A phenolic fragrance compound that serves dual purposes in skincare formulations as both a scent enhancer and masking agent. Beyond its aromatic properties, this ingredient offers mild antioxidant benefits through its phenolic structure, helping to neutralize free radicals that contribute to skin aging.

Summary

Perfuming Masking Antioxidant

Science

Mechanism of Action

Works primarily through fragrance modulation while providing secondary antioxidant protection via its phenolic structure, which can scavenge free radicals and potentially reduce oxidative stress on skin cells.

Research

Clinical Evidence

Medium confidence
Effective range 0.17–1%
Optimal

0.17%

Key findings

  1. 01 Established No Expected Sensitization Induction Level (NESIL) at 1700 μg/cm² through analog assessment, confirming safety profile for cosmetic applications

Transparency

Dusting Analysis

Not commonly dusted

Primarily used as a functional fragrance ingredient rather than an active, making dusting unlikely in skincare formulations.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Demonstrates good thermal stability with high pKa (~10.3) ensuring stability across typical cosmetic pH ranges, though requires protection from oxidizing conditions.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Iron salts

Safety

Safety Profile

CIR Status
Not reviewed by CIR, but evaluated under RIFM and IFRA guidelines
Max tested
1%
Sensitization risk Low

FDA GRAS status for food use and established NESIL data support safety profile, with IFRA restrictions maintaining low sensitization potential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Optional

A safe, well-tolerated fragrance ingredient with mild antioxidant benefits, suitable for non-sensitive skin types seeking enhanced sensory experience.

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References

Sources