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Moumoujus

4,4'-ISOPROPYLIDENEDIPHENOL.

Avoid CAS 80-05-7 / NOT REPORTED

Commonly known as Bisphenol A (BPA), this synthetic compound functions primarily as an endocrine disruptor and potent skin sensitizer with high dermal penetration capabilities. While occasionally appearing in cosmetic formulations as a film-forming monomer or plasticizer, it presents significant safety concerns due to its xenoestrogenic properties and classification as a carcinogenic, mutagenic, and reprotoxic substance.

Summary

Film former Plasticizer Resin monomer

Science

Mechanism of Action

Acts as a xenoestrogen by mimicking natural hormone activity and disrupting endocrine function, while simultaneously triggering allergic contact dermatitis through haptinization processes that sensitize the skin's immune response

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 ECHA CLH Report demonstrating skin sensitization and xenoestrogenic activity at 0.1-1.0% concentrations with high dermal penetration potential

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.001%

Presence above trace levels indicates potential regulatory violations and safety risks due to its prohibited status in multiple jurisdictions

The Formula

Formulation

Solubility
Both
Optimal pH 6 – 8
0 7 14

Stability

Thermally stable below 220°C with a pKa of 9.6, but exhibits high reactivity with oxidizing agents and acid derivatives

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Acid chlorides
  • Acid anhydrides

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.001%
Pregnancy
Caution
Sensitization risk High

Prohibited in EU cosmetics under Regulation 1223/2009 Annex II and restricted in multiple jurisdictions due to CMR Category 1B classification and endocrine-disrupting properties

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

A regulated contaminant with established endocrine-disrupting and sensitizing properties that should be avoided in all skincare formulations.

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