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Moumoujus

3-NITRO-P-CRESOL.

Avoid CAS 2042-14-0 / HAIR DYEING

A nitro-substituted phenolic compound primarily designed for hair coloring applications. Despite its chemical structure suggesting potential skin-active properties, this ingredient lacks established benefits for skincare and carries concerning depigmentation risks.

Summary

colorant

Science

Mechanism of Action

Functions as a direct dye that penetrates due to its low molecular weight, but in skincare contexts may interfere with melanogenesis pathways, potentially disrupting normal pigmentation processes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Related p-cresol compounds demonstrated skin and hair depigmentation effects in animal studies, raising safety concerns for topical use

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is not typically used in skincare formulations and would be inappropriate for inclusion in cosmetic products intended for facial or body care.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6
0 7 14

Stability

Requires protection from air oxidation and light exposure; best stored under inert atmosphere in opaque containers

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Air exposure

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

CIR Expert Panel determined insufficient safety data exists for leave-on applications due to chemical leukoderma concerns and absence of dose-response studies

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

This hair dye ingredient has no established skincare benefits and presents significant depigmentation risks that make it unsuitable for cosmetic use.

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