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2-TERT-BUTYL-4-METHYL-CYCLOHEXANOL ACETATE.

Optional CAS 115724-27-1 / PERFUMING

A cyclohexane derivative primarily employed as a fragrance component in cosmetic formulations. This acetate ester possesses structural similarities to 4-t-butylcyclohexanol, a known TRPV1 receptor antagonist, potentially offering dual benefits as both a perfuming agent and a mild skin-soothing compound when hydrolyzed.

perfuming fragrance

Science

Functions primarily as a lipophilic fragrance molecule that penetrates the stratum corneum. Upon potential hydrolysis to its parent alcohol form, may act as a TRPV1 receptor antagonist, modulating overactive nerve endings to reduce skin reactivity and sensory irritation.


Research

Medium confidence
Effective range 0.1–5%
Optimal

1%

Key findings

  1. 01 Related cycloalkane derivatives demonstrate significant reduction in stinging and burning sensations through TRPV1 receptor inhibition
  2. 02 Human Repeat Insult Patch Tests show no significant sensitization or irritation in fragrance acetate mixtures

Transparency

Not commonly dusted

Primarily used as a fragrance component rather than an active ingredient, making dusting practices uncommon in this category


The Formula

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Ester bond susceptible to hydrolysis under extreme pH conditions, converting to parent alcohol and acetic acid

Conflicts

  • Strong oxidizing agents
  • Highly alkaline environments

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Evaluated by RIFM and IFRA for fragrance safety. No genotoxicity or photoirritation concerns identified in standard assessments.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient with potential mild skin-soothing properties, suitable for various formulations but not essential for efficacy.


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