Science
Mechanism of Action
Functions as a neurosensory modulator by blocking TRPV1 (vanilloid) receptors in skin tissue, which elevates the threshold for irritant perception and dampens neural signals responsible for stinging, burning, and itching sensations.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 HRIPT studies at 1% concentration demonstrated significant reduction in stinging and burning sensations in sensitive skin subjects (RIFM/Symrise)
Transparency
Dusting Analysis
Primarily used as a functional fragrance ingredient with therapeutic benefits rather than for marketing appeal
The Formula
Formulation
Stability
Demonstrates excellent thermal stability and pH tolerance across a wide range; integrates seamlessly into oil phases and anhydrous formulations
Synergies
- Other soothing actives in sensitive skin formulations
- Oil-phase emollients
Conflicts
- Strong oxidizing agents
- Highly polar aqueous systems without solubilizers
Safety
Safety Profile
Extensively evaluated by RIFM and IFRA with established safety limits for leave-on products; potential for sensitization exists in small population subsets above recommended concentrations
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed dual-function ingredient that provides measurable sensory comfort benefits beyond traditional fragrance applications.
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References
Sources
Keep exploring
From ingredients to everyday care.
Sensitive skin ↗
Start with comfort, product choices and the questions to ask.
Barrier support ↗
Understand moisture, lipids and the limits of ingredient claims.
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