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Moumoujus

2-NAPHTHOL.

Avoid CAS 135-19-3 / HAIR DYEING, PERFUMING

2-Naphthol is a potent keratolytic compound that functions as an intensive peeling agent, primarily utilized in medical-grade acne treatments. This naphthalene derivative delivers aggressive exfoliation by promoting stratum corneum shedding while providing antiseptic benefits. Due to its high reactivity and significant irritation potential, it remains largely restricted to specialized dermatological applications.

Summary

Keratolytic Antiseptic Peeling agent Hair dye coupler

Science

Mechanism of Action

Functions as an aggressive keratolytic agent that disrupts the stratum corneum structure, forcing rapid cellular turnover and exfoliation. As a phenol homologue, it induces controlled tissue irritation that stimulates skin renewal processes while delivering antiseptic properties to combat acne-causing bacteria.

Research

Clinical Evidence

Medium confidence
Effective range 5–20%
Optimal

20%

Key findings

  1. 01 Medical peeling pastes at 20% concentration demonstrated efficacy in acne vulgaris treatment, with 5-12.5% dermal absorption rates (OECD SIDS 2002)

Transparency

Dusting Analysis

Not commonly dusted

Not applicable for cosmetic dusting as this ingredient is banned in EU cosmetics and restricted to medical applications

The Formula

Formulation

Solubility
Both
Optimal pH 7 – 9.5
0 7 14

Stability

Exhibits significant photodegradation and darkening upon light exposure. Requires careful pH management around its pKa of 9.51 for optimal stability.

Conflicts

  • Strong oxidizing agents
  • Phenol
  • Strong acids
  • Strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Pregnancy
Caution
Sensitization risk High

Banned as cosmetic ingredient in EU (Annex II/382) except as hair dye coupler. Limited to medical peeling applications due to high irritation potential.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Too aggressive for consumer skincare with significant regulatory restrictions and high irritation risk.

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References

Sources