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Moumoujus

2-METHYLRESORCINOL.

Questionable CAS 608-25-3 / HAIR DYEING

2-Methylresorcinol is a phenolic compound primarily recognized for its role in hair coloring but occasionally utilized in skincare formulations for its antioxidant properties. While it demonstrates ROS scavenging ability and potential tyrosinase inhibition, its classification as a moderate skin sensitizer limits its broader cosmetic applications. The ingredient requires careful formulation consideration due to its sensitization potential at higher concentrations.

Summary

antioxidant tyrosinase inhibitor hair dyeing agent

Science

Mechanism of Action

Functions as an antioxidant by neutralizing reactive oxygen species that contribute to skin aging and oxidative damage. May also inhibit tyrosinase enzyme activity, potentially reducing melanin production and supporting skin tone evenness.

Research

Clinical Evidence

Medium confidence
Effective range 1.8–1.8%
Optimal

1.8%

Key findings

  1. 01 SCCS dermal absorption study showing 0.28-0.40 µg/cm² absorption rates at 1.8% concentration
  2. 02 LLNA sensitization study identifying EC3 value of 50% with no significant reaction below 25%

Transparency

Dusting Analysis

Not commonly dusted

Primarily used in hair products rather than skincare, making dusting practices less relevant for this ingredient

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 10
0 7 14

Stability

Requires protection from air and light exposure to prevent oxidative browning. Best stored at 0-8°C for raw material stability.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Acid chlorides
  • Acid anhydrides

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1.8%
Sensitization risk Moderate

EU regulated under Annex III/243 with 1.8% maximum concentration for oxidative hair formulations. Moderate skin sensitizer classification requires careful usage consideration.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Limited skincare relevance due to moderate sensitization risk and primary hair dyeing function, with insufficient evidence for significant skin benefits.

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