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2-METHYLPROPANAL.

Questionable CAS 78-84-2 / NAIL CONDITIONING, PERFUMING

A volatile aldehyde compound that serves primarily as a fragrance component, delivering sharp, fruity aromatic notes to cosmetic formulations. This highly reactive molecule functions as both a scenting agent and formulation solvent, though its volatility and potential for irritation limit its widespread use. Research reveals it naturally occurs as a skin-emitted volatile organic compound that correlates with chronological aging processes.

fragrance solvent

Science

Functions through its electrophilic carbonyl carbon structure to provide immediate olfactory impact while serving as a chemical intermediate in formulations. Its high volatility allows for rapid evaporation and scent delivery, while its aldehyde structure makes it prone to oxidative conversion to isobutyric acid over time.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Naturally emitted from human skin with levels correlating to chronological age and surface pH variations
  2. 02 Identified as microbial degradation product of common cosmetic plasticizers rather than endogenous metabolite

Transparency

Not commonly dusted

Primarily used as fragrance component rather than active ingredient, making dusting practices less relevant for this compound.


The Formula

Solubility
Both
Optimal pH 5.8 – 6.5
0 7 14

Stability

Extremely volatile with flash point of -40°F, requiring careful storage and handling. Degrades rapidly under acidic or alkaline conditions, converting to isobutyric acid through oxidation.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Strong acids
  • Prolonged air exposure

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

FDA-approved for direct food addition under 21CFR172.515. Often confused with banned EU ingredient Butylphenyl Methylpropional (Lilial). Causes skin, eye, and respiratory irritation at elevated concentrations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Limited skincare benefits with notable irritation potential and formulation challenges make this primarily suitable for fragrance applications only.


Related

Finding similar ingredients…


References