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2-METHYLBUTYRALDEHYDE.

Optional CAS 96-17-3 / PERFUMING

A branched-chain aliphatic aldehyde primarily used as a fragrance component in skincare formulations. This volatile compound delivers distinctive cocoa, nutty, and fruity aromatic notes while remaining chemically reactive through its aldehyde functional group. At safe concentrations, it provides sensory enhancement without therapeutic benefits.

perfuming

Science

Functions as an olfactive agent through molecular interaction with olfactory receptors, providing fragrance benefits. The aldehyde functional group can form Schiff bases with skin proteins, which may contribute to potential irritation at higher concentrations but does not provide therapeutic skin benefits.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 No skin sensitization reactions observed in human maximization testing
  2. 02 Non-sensitizing in murine local lymph node assay

Transparency

Not commonly dusted

Primarily used as fragrance component in regulated concentrations, not commonly subject to dusting practices due to volatility and irritation potential at high levels.


The Formula

Solubility
Both
Optimal pH 5 – 8
0 7 14

Stability

Highly volatile with boiling point 90-93°C, air-sensitive and prone to oxidation forming 2-methylbutyric acid. Limited water solubility (11g/L) but miscible in alcohols and oils.

Conflicts

  • Strong oxidizing agents
  • Strong bases (alkalis)
  • Strong reducing agents
  • Primary amines

Safety

CIR Status
Not reviewed
Max tested
0.3%
Sensitization risk Low

RIFM Expert Panel concluded safe for current fragrance practices. IFRA maximum 0.3% in fragrance concentrates. FDA GRAS status as flavoring agent.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Optional

A safe fragrance component at regulated concentrations that provides sensory enhancement without therapeutic skin benefits.


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