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Moumoujus

2-METHYLBUTANOL.

Optional CAS 137-32-6 / PERFUMING

A branched-chain alcohol primarily utilized as a fragrance component and solvent in cosmetic formulations. This volatile compound can disrupt the skin barrier by extracting stratum corneum lipids, potentially enhancing penetration of other ingredients. While generally well-tolerated at low concentrations, its barrier-disrupting properties limit its suitability for sensitive or compromised skin.

Summary

perfuming solvent penetration enhancer

Science

Mechanism of Action

Functions by extracting lipids from the stratum corneum and fluidizing lamellar membranes, which disrupts the skin barrier structure and can facilitate enhanced penetration of accompanying active ingredients

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

1%

Key findings

  1. 01 Human maximization test at 1.0% showed no sensitization reactions in petrolatum vehicle (RIFM, 1978)
  2. 02 Murine lymph node assay demonstrated non-sensitizing properties at 25.0% concentration (Food and Chemical Toxicology, 2021)
  3. 03 Pure concentration (100%) caused skin irritation and potential sensitization due to irritant effects (ECHA, 2015)

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.5%
Red flag below
1.5%

Rarely used as dusting due to its specific fragrance and solvent applications, with clear concentration limits established by industry standards

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Highly volatile and flammable compound that remains stable up to 15% in fragrance oils without decomposition; demonstrates superior stability in slightly acidic to neutral pH environments typical of cosmetic products

Synergies

  • Botanical extracts (enhanced penetration)
  • Other fragrance components

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Hydrogen trisulfide
  • Alkaline earth metals

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

Assessed by RIFM and Expert Panel for Cosmetic Ingredient Safety as part of branched chain saturated alcohols group; IFRA standards recommend maximum 1.0% in fragrance concentrates

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Optional

A functional fragrance component and solvent that's safe at regulated concentrations but offers limited skincare benefits beyond scent and potential penetration enhancement.

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References

Sources