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2-METHYL-4-(2,6,6-TRIMETHYL-1-CYCLOHEXENYL)-2-BUTENAL.

Questionable CAS 3155-71-3 / PERFUMING

A fragrance compound structurally related to beta-ionone that serves as both a perfuming agent and an intermediate in vitamin A synthesis pathways. While it shares chemical ancestry with retinol precursors, this ingredient functions exclusively as a scent component in skincare formulations without providing retinoid-like biological activity.

perfuming

Science

Functions purely as a fragrance molecule to enhance product sensory experience, with no direct skin-beneficial mechanisms beyond olfactory enhancement


Research

Medium confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 RIFM fragrance safety assessment determining skin sensitization NESIL of 2900 μg/cm² at 0.1-1.0% concentrations

Transparency

Not commonly dusted

As a restricted fragrance material with known sensitization potential, this ingredient is typically used at carefully controlled concentrations rather than being added arbitrarily


The Formula

Solubility
Oil
Optimal pH 4 – 7.5
0 7 14

Stability

Demonstrates excellent stability in standard cosmetic matrices including lotions and cleansers, but degrades rapidly in high-pH or oxidizing environments due to its highly lipophilic nature (logP 4.0-4.5)

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Hypochlorite compounds

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk High

IFRA-restricted fragrance material classified as Category 1 skin sensitizer; 2023 RIFM assessment supports safe use within established concentration limits


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

A fragrance-only ingredient with significant sensitization risk that adds no functional skincare benefits beyond scent enhancement.


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