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2-METHOXYMETHYL-P-AMINOPHENOL HCL.

Avoid CAS 135043-65-1 / HAIR DYEING

A specialized chemical intermediate primarily designed for hair coloring applications, functioning as a precursor molecule in oxidative dye systems. This small molecular weight compound penetrates hair shafts under alkaline conditions and polymerizes to create permanent color deposits. While approved for hair use at controlled concentrations, it carries significant sensitization risks and is not intended for facial skincare applications.

hair dyeing color intermediate

Science

Functions as a primary intermediate in oxidative coloring by penetrating hair cortex under alkaline pH conditions, then undergoing oxidation and coupling reactions to form large, stable pigment polymers trapped within hair structure


Research

High confidence
Effective range 0.5–1.02%
Optimal

1.02%

Key findings

  1. 01 SCCS evaluation (SCCS/1381/10) established safety at maximum 1.02% concentration in oxidative hair dye formulations
  2. 02 Parent compound studies demonstrate primary intermediate activity with notable sensitization potential in patch testing

Transparency

Not commonly dusted

Not applicable for skincare formulations as this ingredient is restricted to hair coloring applications only


The Formula

Solubility
Water
Optimal pH 7 – 10
0 7 14

Stability

Requires oxygen-free, light-protected environments for stability; commonly paired with antioxidants like Sodium Sulfite; highly reactive with oxidizing agents

Synergies

  • Sodium Sulfite (antioxidant protection)
  • Coupler molecules (for color formation)
  • Alkaline buffers (for pH optimization)

Conflicts

  • Oxidizing agents (premature reaction)
  • Strong acids (pH incompatibility)
  • Heavy metal ions (discoloration risk)

Safety

CIR Status
Safe with restrictions
Max tested
1.02%
Sensitization risk High

European SCCS approval limited to hair and professional eyelash applications only; classified as skin sensitizer with allergenic potential


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

Specialized hair coloring ingredient with high sensitization risk, inappropriate for facial skincare applications.


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