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2-ISOPROPYL-4-METHYLANISOLE.

Optional CAS 31574-44-4 / PERFUMING

A naturally occurring aromatic compound found in botanical essential oils that serves primarily as a fragrance ingredient in skincare formulations. This methylated phenol derivative offers potential antimicrobial and antioxidant benefits while contributing to product sensory experience through its distinctive olfactory profile.

Fragrance Potential antimicrobial Antioxidant support

Science

Functions through its lipophilic structure to integrate into microbial cell membranes, potentially disrupting pathogenic organisms. As a structural analog of thymol and carvacrol, it may neutralize free radicals and provide mild anti-inflammatory effects on skin tissue.


Research

Low confidence
Effective range 0.11–4.58%
Optimal

N/A

Key findings

  1. 01 Essential oil studies demonstrate antimicrobial activity against fungal pathogens at 0.11-4.58% concentration ranges
  2. 02 In vitro research shows potential antiproliferative effects on human keratinocyte and melanoma cell lines

Transparency

Not commonly dusted

Primarily used as fragrance component rather than active ingredient, making dusting practices unlikely in precision skincare formulations


The Formula

Solubility
Oil
Optimal pH 5.5 – 8
0 7 14

Stability

Demonstrates high chemical stability due to aromatic ether structure. Heat and prolonged light exposure may compromise olfactory characteristics. Activity peaks at pH 5.5 while stability optimizes at pH 8.0.

Conflicts

  • Strong oxidizing agents
  • Strong acids

Safety

CIR Status
Not reviewed
Sensitization risk Low

Listed on IFRA Transparency List as fragrance ingredient. Classified as low hazard in GHS assessments, though undiluted forms may cause mild skin or respiratory irritation.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A safe fragrance ingredient with theoretical skin benefits but limited clinical validation for therapeutic skincare applications.


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