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2-ETHYLHEXANOL.

Optional CAS 104-76-7 / NOT REPORTED

A branched-chain fatty alcohol primarily used as a formulation intermediate and low-volatility solvent in cosmetics. While it provides skin-conditioning properties by reducing transepidermal water loss, its medium irritancy profile limits its direct application in skincare products.

solvent skin conditioning fragrance component formulation intermediate

Science

Forms a protective film on the skin surface to prevent moisture loss while serving as a carrier that enhances the spreadability and absorption of other active ingredients in formulations.


Research

High confidence
Effective range 0–4%
Optimal

4%

Key findings

  1. 01 Human patch testing at 4% concentration showed no irritation or sensitization in 29 volunteers after 48 hours (Kligman, 1976)
  2. 02 Animal studies established dermal NOAEL of 252 mg/kg/day, with higher concentrations causing skin irritation (Tyl et al., 1992)

Transparency

Not commonly dusted

Primarily used as an industrial intermediate rather than a direct cosmetic ingredient, making dusting less relevant for consumer products.


The Formula

Solubility
Oil
Optimal pH 4 – 9
0 7 14

Stability

Exhibits high stability under standard conditions due to its neutral primary alcohol structure, with resistance to oxidation but potential reactivity with strong acids.

Synergies

  • Waxes
  • Resins
  • Emollient esters

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Acid chlorides
  • Acid anhydrides

Safety

CIR Status
Safe as used
Max tested
4%
Sensitization risk Moderate

CIR Expert Panel approved when formulated to minimize irritation. More commonly used as precursor for safer derivatives like Ethylhexyl Palmitate.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Optional

A functional but limited ingredient best utilized as a formulation intermediate rather than a primary skincare active due to moderate irritancy concerns.


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