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2-AMINOMETHYL-P-AMINOPHENOL HCL.

Avoid CAS 135043-64-0 / HAIR DYEING

A hydrochloride salt compound primarily functioning as an oxidative hair dye intermediate that creates permanent color through chemical reactions with hydrogen peroxide. This ingredient lacks established skin-beneficial properties and carries significant sensitization concerns that limit its cosmetic applications. Its primary role remains confined to professional hair coloring formulations rather than skincare treatments.

Hair dyeing intermediate

Science

Functions through oxidative coupling reactions where it serves as a precursor molecule that combines with hydrogen peroxide to form larger chromophore compounds within hair shafts. No recognized dermatological mechanism exists for skin improvement or therapeutic benefits.


Research

Low confidence
Effective range 0.1–2%
Optimal

N/A

Key findings

  1. 01 SCCS evaluation showed sensitization concerns at 2.0% concentration in hair dye applications with limited safety margin

Transparency

Not commonly dusted
Red flag below
0.1%

Not typically used in skincare formulations due to regulatory restrictions and lack of skin benefits


The Formula

Solubility
Water
Optimal pH 3 – 6
0 7 14

Stability

Exhibits optimal stability in acidic environments as the hydrochloride salt form. Prone to oxidative degradation and discoloration when exposed to air or alkaline conditions.

Conflicts

  • Strong oxidizing agents
  • Alkaline pH environments above 7.0
  • Metal ion complexes

Safety

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Caution
Sensitization risk High

EU regulations classify this as prohibited in certain leave-on cosmetic applications due to high sensitization potential. Maximum 1.0% concentration recommended for hair dye applications only.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

This hair dye intermediate offers no proven skincare benefits while presenting significant sensitization risks that make it unsuitable for facial or body care formulations.


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