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Moumoujus

2-AMINO-4-HYDROXYETHYLAMINOANISOLE.

Questionable CAS 83763-47-7 / HAIR DYEING

A specialized coupler compound primarily used in oxidative hair coloring systems to create permanent color through chemical reactions with hydrogen peroxide. While effective for hair dyeing applications, this ingredient carries allergy risks and shows limited skin penetration below 2% of applied dose. Its use is restricted to specific concentrations and formulations due to safety considerations around nitrosation potential.

Summary

hair dyeing

Science

Mechanism of Action

Acts as a reactive coupler that combines with primary intermediates like p-phenylenediamine in the presence of hydrogen peroxide to form large, stable pigment molecules within hair shafts during oxidative dyeing processes

Research

Clinical Evidence

High confidence
Effective range 1.4–3%
Optimal

1.5%

Key findings

  1. 01 Patch testing in 902 dermatitis patients revealed 1.4% positive allergic reaction rate
  2. 02 OECD safety studies at 3% concentration showed slight irritation without hazard classification
  3. 03 Cutaneous absorption studies demonstrated less than 2% skin penetration at 1.5% concentration

Transparency

Dusting Analysis

Not commonly dusted

Not applicable for dusting analysis as this ingredient is specifically formulated for hair coloring applications rather than skincare products

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 10
0 7 14

Stability

Requires alkaline conditions (pH 9-10) for optimal stability and function; sensitive to nitrosating agents and must be stored in nitrite-free containers

Synergies

  • Primary intermediates (p-phenylenediamine)
  • Hydrogen peroxide oxidizing systems

Conflicts

  • Nitrosating agents
  • Nitrites
  • Strong oxidizing agents (pre-reaction)
  • Nitrosating systems

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1.5%
Sensitization risk Moderate

Approved for oxidative hair dye formulations only; prohibited in products where N-nitroso compound formation may occur; maximum on-head concentration limited to 1.5% per EU SCCS and CIR recommendations

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

A specialized hair dyeing ingredient with proven allergenic potential and strict regulatory limitations that make it unsuitable for general skincare applications.

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