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Moumoujus

2-AMINO-3-NITROPHENOL.

Avoid CAS 603-85-0 / HAIR DYEING

A specialized aromatic compound primarily utilized as a precursor molecule in hair coloring formulations. This nitroaniline derivative functions through oxidative coupling reactions to create permanent colorant complexes within hair fibers. While effective for its intended purpose, it presents notable sensitization concerns that limit its broader cosmetic applications.

Summary

hair dyeing

Science

Mechanism of Action

Functions as a colorant precursor that penetrates hair shafts and undergoes electrophilic substitution or oxidative coupling reactions when combined with hydrogen peroxide. Forms large, stable pigment molecules that become trapped within the hair cortex. On skin contact, exhibits protein-denaturing effects typical of phenolic compounds, leading to potential sensitization responses.

Research

Clinical Evidence

High confidence
Effective range 1.5–3%
Optimal

3%

Key findings

  1. 01 SCCNFP evaluation at 3.0% concentration deemed safe for semi-permanent applications
  2. 02 SCCS Opinion confirmed sensitization risk requiring mandatory warning labels
  3. 03 CIR assessment of 2.0-9.0% usage range concluded safety within specific concentration limits

Transparency

Dusting Analysis

Not commonly dusted

Specialized hair dye ingredient with restricted usage patterns - not typically subject to concentration manipulation in consumer products

The Formula

Formulation

Solubility
Both
Optimal pH 8 – 12
0 7 14

Stability

Requires alkaline conditions for optimal performance. Maintains stability for up to 4 hours at room temperature in appropriate solvents. Highly sensitive to light exposure and oxidative degradation, necessitating inert atmosphere storage.

Synergies

  • hydrogen peroxide for permanent coloring
  • alkaline activators

Conflicts

  • strong oxidizing agents
  • strong acids
  • acidic environments
  • light exposure

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
3%
Sensitization risk High

Maximum 3.0% in semi-permanent hair dyes, 1.5% in permanent formulations post-H2O2 dilution. Confirmed skin sensitizer requiring warning labels in EU jurisdictions. Restricted to hair coloring applications only.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Specialized hair dye ingredient with confirmed sensitization risks that make it unsuitable for precision skincare applications.

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