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2,6-DIAMINOPYRIDINE SULFATE.

Avoid CAS 146997-97-9 / HAIR DYEING

A specialized coupling agent primarily used in oxidative hair dye formulations rather than traditional skincare products. This sulfate salt of 2,6-diaminopyridine functions through electrophilic aromatic substitution to create colored pigment molecules when combined with developers and oxidizing agents.

hair dyeing

Science

Functions as a coupler in oxidative reactions, working with primary intermediates and hydrogen peroxide to form large colored molecules within hair shafts through electrophilic aromatic substitution processes


Research

High confidence
Effective range 0.15–3%
Optimal

0.15%

Key findings

  1. 01 SCCS safety assessment confirmed consumer-safe maximum concentration for oxidative hair dye applications after hydrogen peroxide mixing
  2. 02 Human epidermis testing via Episkin model demonstrated non-irritant classification under controlled conditions

Transparency

Not commonly dusted

Not applicable for skincare formulations as this ingredient is exclusively used in hair dye applications with strict regulatory concentration limits


The Formula

Solubility
Water
Optimal pH 6 – 10
0 7 14

Stability

Excellent stability in dry powder form with 8-day solution stability at room temperature; alkaline environments enhance oxidative dyeing reactions

Conflicts

  • Strong oxidizing agents outside controlled reactions
  • Strong reducing agents
  • Nitrosating agents due to nitrosamine formation potential

Safety

CIR Status
Safe with restrictions
Max tested
0.15%
Sensitization risk High

European Annex III regulations restrict maximum 0.15% concentration after mixing; prohibited for eyelash and eyebrow applications; classified as strong skin sensitizer


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Avoid

Specialized hair dye ingredient with high sensitization potential and no established skincare benefits, making it unsuitable for precision skincare formulations.


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