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2,6,6-TRIMETHYLCYCLOHEXENE-1-CARBALDEHYDE.

Optional CAS 432-25-7 / PERFUMING

A naturally-derived apocarotenoid aldehyde that functions as both a fragrance component and cellular signaling molecule. While primarily used for its pleasant herbal scent profile, emerging research suggests it may support skin's defense mechanisms against photo-oxidative stress through gene expression modulation.

fragrance antioxidant cellular signaling molecule

Science

Functions as an apocarotenoid messenger that activates cellular detoxification pathways and enhances tolerance to photo-oxidative damage by regulating gene expression, specifically targeting protection against singlet oxygen and reactive oxygen species generated during light exposure.


Research

Medium confidence
Effective range 0.001–2%
Optimal

0.01%

Key findings

  1. 01 RIFM safety assessment at 2.0% concentration showing no skin sensitization concerns with DST of 64 μg/cm²
  2. 02 Biological models demonstrated strongest stress resistance effects at 10 μM concentration for photo-oxidative protection

Transparency

Not commonly dusted

Primarily used as a fragrance ingredient rather than an active skincare component, so dusting practices are not commonly associated with this ingredient.


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Highly susceptible to oxidative degradation and requires inert gas storage or antioxidant protection; unstable above pH 8-10 due to aldehyde condensation reactions

Synergies

  • antioxidants
  • inert atmospheric packaging

Conflicts

  • strong oxidizing agents
  • strong bases
  • direct UV exposure
  • oxygen exposure

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

RIFM and IFRA assessed as non-genotoxic and non-phototoxic with FEMA GRAS status for flavoring applications; no skin sensitization concerns at declared usage levels


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient with emerging potential as a photo-protective antioxidant, though primarily valuable for scent rather than proven skincare benefits.


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