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2,6,6-TRIMETHYL-2-CYCLOHEXENE-1-ACETALDEHYDE.

Optional CAS 472-64-0 / PERFUMING

A camphoreous aldehyde compound that serves primarily as a fragrance component, delivering woody and cooling olfactory notes to skincare formulations. Beyond its perfuming properties, this ingredient may influence sensory signaling through interaction with TRPA1 and TRPV1 receptors in skin cells.

perfuming

Science

Functions as a perfuming agent while potentially activating TRPA1 and TRPV1 receptors in skin cells, which can modulate peripheral sensory signaling and contribute to cooling or warming sensations depending on concentration and receptor co-expression patterns.


Research

Medium confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 RIFM established No Expected Sensitization Induction Level (NESIL) of 1100 μg/cm² for safe fragrance use at evaluated concentrations of 0.1-1.0%

Transparency

Not commonly dusted

Primarily used as a fragrance component at low concentrations rather than for active skincare benefits, making dusting unlikely and unnecessary.


The Formula

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

Aldehyde structure makes it susceptible to oxidation from air and light exposure; commonly stabilized through dilution in dipropylene glycol or ethanol at 10% concentrations; prone to Schiff base formation with primary amines

Conflicts

  • Strong oxidizing agents
  • Primary amines
  • Strongly alkaline environments

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Moderate

RIFM and IFRA assessed with established NESIL of 1100 μg/cm²; cleared under Threshold of Toxicological Concern for systemic toxicity; use restrictions apply primarily for sensitization prevention in leave-on products


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A functional fragrance ingredient with established safety parameters that serves its perfuming purpose effectively but offers limited direct skincare benefits beyond sensory enhancement.


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References