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2,6,6-TRIMETHYL-1-CYCLOHEXENE-1-ACETALDEHYDE.

Optional CAS 472-66-2 / PERFUMING

A volatile aldehyde fragrance compound that delivers camphoraceous, woody, and cooling aromatic notes to skincare formulations. This alpha-hydrogen aldehyde serves primarily as a perfuming agent while also functioning as a precursor in the synthesis of bioactive terpenic molecules.

perfuming

Science

Functions through organoleptic pathways by releasing volatile compounds that stimulate olfactory receptors, creating sensory enhancement in skincare products without direct dermatological benefits


Research

Medium confidence
Effective range 0.0025–0.1%
Optimal

0.0025%

Key findings

  1. 01 SCCS safety evaluation at 0.0025% concentration for fragrance use
  2. 02 RIFM bacterial reverse mutation assays showed no mutagenic activity up to 5000 μg/plate

Transparency

Not commonly dusted
Min. effective
0.01%
Red flag below
0.1%

Regulated fragrance ingredient with established safety limits; concentrations above 0.1% may indicate formulation issues or regulatory non-compliance


The Formula

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

Air and light sensitive requiring inert atmosphere storage; susceptible to oxidation in high-water formulations leading to acid formation

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Primary amines

Safety

CIR Status
Not reviewed by CIR
Max tested
0.1%
Pregnancy
Safe
Sensitization risk Low

Regulated by RIFM and IFRA guidelines; classified as Cramer Class I indicating low oral toxicity; SCCS limits acetaldehyde derivatives to 20-100 ppm in finished products


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance component with established safety profile, useful for sensory enhancement but offering no direct skincare benefits.


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References