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2,4-DIAMINODIPHENYLAMINE.

Avoid CAS 136-17-7 / HAIR DYEING

2,4-Diaminodiphenylamine is an aromatic amine compound historically utilized as a coupling agent in oxidative hair coloring systems. This ingredient has been prohibited from cosmetic use in the European Union and multiple other jurisdictions since 2006 due to significant safety concerns. It functions exclusively in hair dyeing applications and has no legitimate role in modern skincare formulations.

hair colouring

Science

Functions as a coupler in oxidative hair dyeing by undergoing polymerization reactions with hydrogen peroxide and other dye precursors to create large pigment molecules. On skin contact, it acts as a hapten that binds to skin proteins, potentially triggering immune sensitization responses.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted
Red flag below
0.1%

Any presence of this banned ingredient in skincare products represents regulatory non-compliance and safety concerns


The Formula

Solubility
Oil
Optimal pH 3 – 5
0 7 14

Stability

Exhibits stability only under acidic conditions below pH 5; becomes highly unstable and prone to degradation at neutral or alkaline pH levels

Conflicts

  • Strong oxidizing agents
  • Nitrosating compounds
  • Alkaline pH environments
  • Hydrogen peroxide systems

Safety

CIR Status
Insufficient data
Max tested
0%
Pregnancy
Caution
Sensitization risk High

Completely banned from cosmetic use in EU under Annex II/1215 and other jurisdictions due to potent contact sensitization potential and insufficient toxicological safety data


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

A banned cosmetic ingredient with documented high sensitization risk that should never appear in skincare products.


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References