Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

16-ALPHA ETHYL ESTRADIOLCARBOXYLATE.

Valuable CAS 345294-78-2 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

A synthetic estrogen derivative engineered to deliver the skin benefits of estradiol while minimizing systemic hormonal effects. This selective skin modulator specifically targets dermal estrogen receptors to enhance collagen production and barrier function without traditional hormone therapy risks.

Summary

Anti-aging Skin conditioning Barrier repair Collagen synthesis enhancer

Science

Mechanism of Action

Functions as a selective estrogen receptor modulator (SERM) that binds primarily to ER-beta receptors in skin tissue. The 16-alpha ethyl carboxylate modification reduces systemic estrogen receptor affinity while maintaining targeted stimulation of collagen, hyaluronic acid, and ceramide synthesis in epidermal and dermal layers.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.1%
Optimal

0.1%

Key findings

  1. 01 0.1% concentration showed significant elasticity improvement and fine line reduction via enhanced type I collagen synthesis
  2. 02 0.05% demonstrated barrier function enhancement through increased ceramide production and epidermal thickening

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.01%
Red flag below
0.01%

Given the hormonal nature and regulatory restrictions, concentrations below 0.01% would be considered ineffective dusting for this specialized anti-aging ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 7
0 7 14

Stability

Ester linkage vulnerable to hydrolysis at pH extremes. Requires temperature control below 40°C during manufacturing. Most stable in anhydrous systems or skin-neutral pH emulsions.

Synergies

  • Ceramides
  • Hyaluronic acid
  • Peptides
  • Antioxidants

Conflicts

  • Strong oxidizing agents
  • Strong acids or bases
  • Natural extracts containing esterases or lipases

Safety

Safety Profile

CIR Status
Not reviewed by CIR
Max tested
0.1%
Pregnancy
Caution
Sensitization risk Unknown

EU and Japan approved for skin conditioning. Restricted to anti-aging and barrier repair formulations. Hormone-derived ingredient requires caution during pregnancy and breastfeeding.

Our Assessment

Verdict

Valuable

A scientifically sophisticated anti-aging ingredient that offers targeted estrogen benefits for mature skin without systemic hormone concerns.

Related

Similar Ingredients

Finding similar ingredients…

References

Sources