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1-TRIMETHYL-3-CYCLOHEXENYLETHANONE.

Questionable CAS 68480-14-8 / PERFUMING

A synthetic fragrance compound structurally related to damascones and ionones, primarily used to mask unpleasant odors in cosmetic formulations. Also known by its trade name Methyl Cyclocitrone, this ingredient serves purely aesthetic functions rather than delivering therapeutic skin benefits.

Perfuming Masking

Science

Functions exclusively as a sensory modifier by binding to olfactory receptors to alter product scent profiles. On skin contact, it can undergo cytochrome P450-mediated oxidation to form reactive epoxide metabolites that may trigger allergic sensitization responses in susceptible individuals.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted
Red flag below
1%

At maximum allowable concentrations of 1.0%, this potent sensitizer poses significant allergic reaction risks that outweigh its cosmetic benefits


The Formula

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Highly susceptible to oxidative degradation and photodegradation due to unsaturated ketone structure. Requires opaque packaging and antioxidant protection systems. Vulnerable to polymerization under extreme pH conditions.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases
  • Primary amines

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk High

Classified as Skin Sensitizer Category 1A/B under ECHA and GHS systems. IFRA regulations restrict usage concentrations in leave-on products due to documented allergenic potential.



Our Assessment

Questionable

High sensitization risk with no proven skin benefits makes this fragrance ingredient unsuitable for precision skincare formulations.


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