Science
Mechanism of Action
Functions by upregulating ANGPTL4 gene expression to inhibit programmed cell death while simultaneously blocking phospholipase A2 activity, potentially reducing inflammatory cascade activation and supporting cellular longevity pathways.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Not established as a cosmetic ingredient; any presence would be experimental or mislabeling given its primary registration as a pesticide compound
The Formula
Formulation
Stability
Exhibits pronounced photosensitivity requiring UV protection, particularly unstable in alkaline conditions with tendency toward decarboxylation; pKa 4.23-4.24 favors acidic formulations
Conflicts
- Strong oxidizing agents
- Alkaline ingredients
- UV-generating actives
- Sulfate-based compounds
Safety
Safety Profile
Classified as Category 2 skin irritant and Category 1 eye irritant under GHS; lacks cosmetic safety assessment and established dermal exposure limits for consumer products
Our Assessment
Verdict
Despite intriguing cellular mechanisms, safety classification as an irritant and lack of cosmetic regulatory approval make this unsuitable for skincare applications.
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References
Sources