Science
Mechanism of Action
As a strong alkali, 1,6-Hexanediamine actively adjusts the pH of a formulation by reacting with electrophilic groups. Its function in cosmetic formulations is limited to pH regulation, offering no direct beneficial effects on the skin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
This ingredient is not a beneficial skin active and its primary role is as a pH regulator with significant corrosive properties, rendering the concept of 'dusting' for efficacy irrelevant.
The Formula
Formulation
Stability
1,6-Hexanediamine is hygroscopic and exhibits instability in air, reacting with both water vapor and carbon dioxide to form insoluble carbonate compounds.
Conflicts
- strong oxidizing agents
- acids
- acid anhydrides
- acid chlorides
- carbon dioxide (CO2)
- metals
Safety
Safety Profile
1,6-Hexanediamine is classified as hazardous, demonstrating corrosivity to both metals and biological tissues, leading to severe skin burns and eye damage. In vitro testing has shown aqueous dilutions as low as 35% to be corrosive (sub-category 1B), and undiluted exposure resulted in irreversible edema and erythema in rabbit studies. Prolonged or repeated skin contact may induce dermatitis. There is no established safety status for its use in cosmetics by regulatory bodies such as CIR, SCCS, or FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its pronounced corrosivity, documented severe skin and eye damage potential, and the absence of established cosmetic safety guidelines, 1,6-Hexanediamine is unequivocally not recommended for skincare formulations.
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References
Sources