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Moumoujus

1,6-HEXAMETHYLENE DIISOCYANATE.

Avoid CAS 822-06-0 / NOT REPORTED

1,6-Hexamethylene Diisocyanate (HDI) is a highly reactive chemical distinguished by its isocyanate functional groups. It readily forms covalent bonds with skin proteins, such as keratin, a characteristic that underpins its recognized irritant and sensitizing profile, with no identified beneficial dermatological actions.

Summary

Science

Mechanism of Action

The mechanism of 1,6-Hexamethylene Diisocyanate involves its extreme reactivity with nucleophilic substances, including water, alcohols, and the amine and hydroxyl groups present in biological proteins. Upon dermal contact, HDI covalently binds to proteins like keratin, which directly contributes to its capacity to induce irritation and sensitization on the skin. This reactivity is not associated with any positive skincare effects.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0%

1,6-Hexamethylene Diisocyanate is unequivocally identified as a significant irritant and sensitizer, with no recognized beneficial utility in skincare formulations. Its presence in any concentration is strictly contraindicated due to substantial safety risks, including allergic contact dermatitis.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

1,6-Hexamethylene Diisocyanate is notably reactive, undergoing rapid degradation via hydrolysis or polymerization when exposed to water. Consequently, it exhibits significant instability in aqueous environments.

Conflicts

  • water
  • alcohols
  • amines

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed 1,6-Hexamethylene Diisocyanate (monomer) for direct cosmetic application, implicitly dictating a maximum concentration of 0%. While CIR has assessed the safety of *HDI polymers* (with the proviso of no significant residual monomers), the HDI monomer itself is a recognized occupational sensitizer and irritant, capable of causing respiratory issues and allergic contact dermatitis upon skin exposure. The EPA has not classified it for carcinogenicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its extreme reactivity, documented irritant and sensitizing properties, and a recommended maximum concentration of 0% for cosmetic use, 1,6-Hexamethylene Diisocyanate must be unequivocally avoided in all skincare formulations.

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