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1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL.

Avoid CAS 74918-21-1 / HAIR DYEING

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL is a chemical compound primarily employed as a coupler in permanent and oxidative hair dye systems. It contributes to the formation of stable color molecules within the hair shaft, enhancing the depth, vibrancy, and wash-fastness of the final hair color.

Hair Dye

Science

This ingredient functions as a coupler in hair coloring processes. Its unique molecular structure, featuring multiple amino groups, facilitates chemical reactions with primary intermediates and an oxidizing agent, such as hydrogen peroxide. This reaction creates stable chromophores inside the hair, which modifies and intensifies the resulting hair color.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

This ingredient's primary application is in hair dye formulations; it is not typically used as a topical skincare active, rendering dusting analysis irrelevant for skin-focused products.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Standard solutions of the test substance in a 30/70 acetonitrile/Milli-Q water mixture demonstrated stability for at least 42.8 hours when stored in the dark at room temperature.


Safety

CIR Status
Not reviewed
Max tested
1.8%
Sensitization risk High

European regulatory bodies, including the SCCNFP (1999) and SCCP (2007), have assessed this substance for use in hair dye formulations. The SCCP established a maximum on-head concentration of 1.8% (calculated as tetrahydrochloride salt, corresponding to 1.2% of the free base) for oxidative hair dyes. Both bodies noted its sensitizing potential, with SCCNFP recommending a warning label. PubChem identifies hazards such as 'May cause an allergic skin reaction' (H317) and 'Causes serious eye irritation' (H319). It is regulated in Europe under the Cosmetics Directive.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Avoid

Primarily a hair dye component with no established skincare benefits and a noted high risk of sensitization and irritation, rendering it unsuitable for precision skincare formulations.


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