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Moumoujus

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE.

Avoid CAS 81892-72-0 / HAIR DYEING

This compound is exclusively utilized as an oxidative hair dye coupler, contributing to the final color formulation by reacting with primary intermediates and an oxidizing agent. It is not intended for use in precision skincare products due to its specific functionality and associated sensitisation risks.

Summary

Hair Dye

Science

Mechanism of Action

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE functions as a secondary intermediate, or coupler, within oxidative hair dye systems. It does not possess intrinsic color but undergoes a chemical reaction with primary dye intermediates in the presence of an oxidizing agent, typically hydrogen peroxide. This reaction leads to the formation of stable chromophores, or color molecules, which are then deposited within the hair shaft, thereby modifying and enhancing the hair's final shade.

Research

Clinical Evidence

High confidence
Effective range 0–1.2%
Optimal

1.2%

Key findings

  1. 01 The Scientific Committee on Consumer Products (SCCP) deemed 1,3-Bis-(2,4-diaminophenoxy)propane and its tetrahydrochloride salt safe for use as an oxidative hair dye at a maximum on-head concentration of 1.8% (calculated as tetrahydrochloride salt), corresponding to 1.2% of the free base. An in-use concentration of 1.0% when mixed with hydrogen peroxide was also noted. A mandatory label warning for sensitisation risk is required.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient's function is strictly as a hair dye component; it holds no recognized utility or common practice for 'dusting' in skincare formulations. Its presence in precision skincare products would be unexpected.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Standard solutions in a 30/70 acetonitrile/Milli-Q water mixture demonstrated stability for a minimum of 42.8 hours when stored at room temperature in darkness. The substance itself exhibits hygroscopic properties. Specific optimal pH ranges for stability in complex formulations are not explicitly provided.

Conflicts

  • Oxidizing agents (if not part of a controlled and intended hair dyeing reaction)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1.2%
Sensitization risk High

The Scientific Committee on Consumer Products (SCCP) concluded this ingredient is safe for its intended use as an oxidative hair dye at a maximum on-head concentration of 1.2% (free base), which equates to 1.8% as its tetrahydrochloride salt. However, a significant risk of sensitisation necessitates a mandatory product label warning. PubChem classifies the substance with hazard statements H317 (May cause an allergic skin reaction) and H319 (Causes serious eye irritation). A specific Cosmetic Ingredient Review (CIR) for this exact compound is not available, though a related substance, 2,4-Diaminophenoxyethanol HCl, has been reviewed and deemed safe for hair dye use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

As an oxidative hair dye coupler with a confirmed high risk of sensitisation and no demonstrated skincare benefits, 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE is not suitable for inclusion in Moumoujus precision skincare formulations.

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